FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE TABLETS OF NORFLOXACIN CONTAINING NATURAL POLYMER
Ritesh Rana, Rohit Bisht, Manoj kumar Sarangi
Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun E-mail: manojsarangi2007@rediffmail.com
Keywords: Norfloxacin, Mucoadhesion, Gastroretention, Tamarind Seed Polysaccharide
Abstract

The present investigation deals with development and evaluation of mucoadhesive gastroretentive tablet of Norfloxacin using natural polymer from Tamrind seed polysaccharide. Natural polymers have been used widely in the sustained release of a variety of drugs to enhance their release patterns. The hypothesis behind this work is to increase the bioavailability of drug by gastro retentive approach. Different formulations (F1 to F12) have been prepared by wet granulation method. Preformulation studies such as melting point, U.V. scanning, solubility studies have been done. Drug polymer compatibility studies were done using FT-IR. Micromeretic studies such as bulk density, tapped density, carr’s index, hausner ratio and angle of repose were performed. Prepared tablets were further evaluated for mucoadhesive strength, swelling index, hardness, weight variation, friability, thickness has also been evaluated. The in- vitro drug release studies has been done or 8hrs by using USP-II apparatus with 0.1 N HCl. Different kinetic models were applied to study the release pattern of drug from the tablet. Based on the results of different studies formulation F10 was selected as best formulation. All the parameters were found within the acceptance limit and the formulated tablet shows extended release for 8 hrs.

Article Information

Identifiers and Pagination:
Year:2016
Volume:8
First Page:11
Last Page:22
Publisher Id:19204159.8:1.2016
Article History:
Received:September 27, 2015
Accepted:October 11, 2015
Collection year:2015
First Published:January 1, 2016


© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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