ASSESSMENT OF CARBIMAZOLE, PROPYLTHIOURACIL & L-THYROXINE FOR LIVER MARKERS IN THYROID PATIENTS FROM PUNJAB, PAKISTAN
Centre for Research in Molecular Medicine, The University of Lahore, Pakistan.Department of Biochemistry, Kinnaird College, Lahore, Pakistan.Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.Department of Pharmaceutical Sciences, Superior University, Lahore, Pakistan.Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.Center for Nuclear Medicine, Mayo Hospital, Lahore, Pakistan.
Keywords: Hepatic dysfunction, carbimazole, propylthiouracil, levothyroxine, thyroid hormones
Abstract

Hepatic functions dependency on thyroid hormones has been reported in many past studies. Momentous change in physiology and chemistry of thyroid gland not only affects the glandular function but also profoundly impinge working of liver markers causing hepatic dysfunction. Consequently, in order to give better response for thyroid diseases, the efficiency of thyroid drug is also calculated in persuading liver markers towards standard ranges which previously have been disturbed due to thyroid invasion. The current study was aimed with the intent to find effect of thyroid drugs on liver markers in Pakistani thyroid population from Mayo Hospital, Lahore, Punjab. Patients of hyper and hypothyroidism on thyroid drugs were recruited in the study and their thyroid and liver profiles were compared with controlled population. Carbimazole and propylthiouracil were administered to hyperthyroid patients and hypothyroid patients were given levothyroxine. The data was analyzed statistically based on p-values for parameters such as triiodothyronine, thyroxine, thyroid stimulating hormone, aspartate aminotransferase and alanine aminotransferase. Potential results were obtained for all parameters with carbimazole and propylthiouracil but only thyroxine and alanine aminotrasferase were stabilized with levothyroxine. So, we suggest use of adjunctive therapy with levothyroxine to be prescribed in hypothyroidism.

Article Information

Identifiers and Pagination:
Year:2015
Volume:7
First Page:85
Last Page:91
Publisher Id:19204159.7:1.2015
Article History:
Received:November 30, 2014
Accepted:December 15, 2014
Collection year:2014
First Published:January 1, 2015


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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