EFFECT OF SUPERDISINTEGRATING AGENT ON THE RELEASE OF METFORMIN HCl FROM IMMEDIATE RELEASE TABLETS
Department of Pharmacy, University of Chittagong, Bangladesh. Department of Pharmacy, Jagannath University, Dhaka, Bangladesh. Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh
Keywords: Super disintegration, Metformin, Immediate release tablet
Immediate release tablet of Metformin HCl needs to formulate for emergency treatment of type-II diabetes. The prime objective of the present research was to formulate immediate release tablet of Metformin HCL for rapid action by using Sodium starch glycolate, Collidon CL and Crosscarmellose Na as super disintegrants.Wet granulationmethod was adapted for the tablet preparation, maize starch used as a diluent, Povidone k-30 as a binder, sodium starch glycolate, collidon CL and crosscarmellose Na as super disintegrants in different concentration (2-5%). Aerosol -200 to provide proper flow characteristics and magnesium stearate as a lubricant. Total nine formations were prepared and evaluated for hardness, thickness, diameter, friability, weight variation, disintegration time and in-vitro drug release. All the formulations were compared for disintegration time and % drug release. All formulations are evaluated for pre-compression and post-compression parameters. The result obtained showed that the selected batch of tablet formulations containing sodium starch glycolate provides a short DT between 40 to 22 seconds, with sufficient crushing strength and acceptable friability.
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