EFFICACY OF THYROID DRUGS IN REVERSING ALTERED RENAL MARKERS DUE TO THYROID AILMENTS IN PATIENTS OF PUNJAB, PAKISTAN
Centre for Research in Molecular Medicine, The University of Lahore, Pakistan.Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.Department of Pharmaceutical Sciences, Superior University, Lahore, PakistanCenter for Nuclear Medicine, Mayo Hospital, Lahore, Pakistan.
Keywords: Thyroid disorder, renal dysfunction, carbimazole, propylthiouracil, thyroxine
Abstract

Thyroid hormones significantly influence the proper growth, development and performance of kidney, and, in case of hormonal imbalance, kidney function is adversely affected. Many studies have been done on thyroid medication to identify their effectiveness in hyper and hypothyroidism, but the true efficacy of thyroid drug should also be acquainted with their capability in normalizing abnormal renal profiles. The present study was based on identifying the effectiveness of routinely used thyroid drugs in Punjab, Pakistan to distinguish their role in renal dysfunction due to thyroid ailment. Patients of hyper and hypothyroidism were included in this study along with normal subjects as control. Hyperthyroid patients were administered carbimazole and propylthiouracil while hypothyroid patients were given thyroxine. The renal profiles of patients were compared with profiles of normal subjects and results were statistically analyzed by using analysis of variance test to identify significance or insignificance of results based on p-values. Results were found to be more promising with all drugs for creatinine and uric acid while no reversal of altered blood urea and blood urea nitrogen was observed. We conclude that although thyroid drugs reverse some of abnormal renal parameters but adjunctive therapy should be recommended to mask associated risks of renal ailment with thyroid disorder.

Article Information

Identifiers and Pagination:
Year:2014
Volume:6
First Page:351
Last Page:356
Publisher Id:19204159.6:4.2014
Article History:
Received:June 19, 2014
Accepted:August 02, 2014
Collection year:2014
First Published:October 1, 2014


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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