EFFICACY OF THYROID DRUGS IN REVERSING ALTERED RENAL MARKERS DUE TO THYROID AILMENTS IN PATIENTS OF PUNJAB, PAKISTAN
Centre for Research in Molecular Medicine, The University of Lahore, Pakistan.Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.Department of Pharmaceutical Sciences, Superior University, Lahore, PakistanCenter for Nuclear Medicine, Mayo Hospital, Lahore, Pakistan.
Keywords: Thyroid disorder, renal dysfunction, carbimazole, propylthiouracil, thyroxine
Thyroid hormones significantly influence the proper growth, development and performance of kidney, and, in case of hormonal imbalance, kidney function is adversely affected. Many studies have been done on thyroid medication to identify their effectiveness in hyper and hypothyroidism, but the true efficacy of thyroid drug should also be acquainted with their capability in normalizing abnormal renal profiles. The present study was based on identifying the effectiveness of routinely used thyroid drugs in Punjab, Pakistan to distinguish their role in renal dysfunction due to thyroid ailment. Patients of hyper and hypothyroidism were included in this study along with normal subjects as control. Hyperthyroid patients were administered carbimazole and propylthiouracil while hypothyroid patients were given thyroxine. The renal profiles of patients were compared with profiles of normal subjects and results were statistically analyzed by using analysis of variance test to identify significance or insignificance of results based on p-values. Results were found to be more promising with all drugs for creatinine and uric acid while no reversal of altered blood urea and blood urea nitrogen was observed. We conclude that although thyroid drugs reverse some of abnormal renal parameters but adjunctive therapy should be recommended to mask associated risks of renal ailment with thyroid disorder.