Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

EFFICACY OF MALAYSIAN HERBAL PRODUCT IN TREATING DIABETES MELLITUS
Sadia Saleem Rao1, Rahila Najam1, Syed Atif Abbas2
1. Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan 2. Jalan Taylor's 47500 Subang Jaya, Selangor Darul Ehsan Malaysia.
Keywords: Alloxan, Momordica charantia, Punica granatum, Lawsonia inermis and Tamarindus indica.
Abstract

Aim of the study was to examine the efficacy of a combination herbal product from Malaysian market. This herbal product is traditionally being used for managing diabetes mellitus. The herbal combination is a mixture of Momordica charantia, Punica granatum, Lawsonia inermis and Tamarindus indica. The drug was administered orally at the dose of 620mg/70kg once daily for the duration of 42 days to alloxan induced diabetic rats. The effects of this herbal combination were compared with standard drug, sulphonylurea (Glibenclamide). Efficacy of the drug was monitored at intervals with respect to fasting and random glucose levels and glycosylated hemoglobin. Results revealed that the combination of four herbs reduced fasting glucose levels and random glucose levels. HbA1C was observed to be less than 7% by this herbal combination. However, the herbal combination failed to produce the efficacy comparable to the standard drug, Glibenclamide.

Article Information

Identifiers and Pagination:
Year:2015
Volume:5
First Page:7
Last Page:12
Publisher Id:CanJAppSci (2015 ). 5. 7-12
Article History:
Received:October 11, 2014
Accepted:December 13, 2014
Collection year:2014
First Published:January 1, 2015


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

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  • Dentistry and Hygiene
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  • Food and Nutrition
  • Health Management
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  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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