Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

EVALUATION OF PHARMACOLOGICAL EFFECT OF MORUS NIGRA EXTRACT ON ANGIOGENESIS USING CHORIOALLANTOIC MEMBRANE (CAM) ASSAY
Mumtaz Akhter
1. Government Post graduate college Chandni Chock Sargodha, Pakistan. 2. Department of statistics University of Sargodha, Pakistan. 3. Faculty of Pharmacy University of Sargodha, Pakistan.
Keywords: Angiogenesis, Morus nigra, CAM assay.
Abstract

Angiogenesis is the process of formation of new blood vessels from the pre-existing blood vessels controlled by various growth regulators. Disturbances of this regulatory process, by different physiological and pathological disorders results in angiogenesis which leads to the progression of tumor formation. The present study was aimed to explore the effect of Morus nigra (Berry), on angiogenesis by using CAM assay on chicken embryo model. Fertilized eggs were incubated on the 5th day at 37 ºC and dose of different dilutions 0.03%, 0.05%, 0.1%, and 0.5% of this plant extract was applied on 6th day. Evaluation of PBVs, SBVs and TBVs, 3D roughness parameters, angular spectrum and abbot curve of treated CAMs was made on 7th day by image probing system (SPIP). Morus nigra showed antiangiogenic effect by reducing the diameter of CAM blood vessels by applying the dilutions of 0.03%, 0.05%, 0.1%, and 0.5% while significant results were obtained at dilution of 0.5%.

Article Information

Identifiers and Pagination:
Year:2015
Volume:5
First Page:24
Last Page:38
Publisher Id:CanJAppSci (2015 ). 5. 24-38
Article History:
Received:May 13, 2015
Accepted:June 28, 2015
Collection year:2015
First Published:July 3, 2015


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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