Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

MANUFACTURING OF NEW FORMULATION OF RIBAVIRIN 200MG CAPSULES
Shabana Naz Shah* and Waseem Shahzad
Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan
Keywords: Ribavirin, New Formulations, Disintegration, Dissolution.
Abstract

Ribavirin are used for the treatment of chronic hepatitis C with compensated liver disease, in the present study we manufactured the new formulations of Ribavirin capsules by using Microcrystalline cellulose PH 102, Di-calcium phosphate, Povidone K 30, Crospovidone, Aerosil 200 and Magnesium stearate. This study is alienated into two phases. The first phase of the study comprises of new formulation of Ribavirin capsules which were prepared. Whereas in the 2nd phase of study new formulation is evaluated for their physical parameters like average weight, weight variation, disintegration time and also evaluated the chemical analysis like dissolution behaviour and assay. All quality control parameters: average weight, weight variation test, disintegration test, dissolution test and assay were carried out specified by BP/USP (British and United state Pharmacopoeia) for capsules. The results showed that all parameters of new formulations are in accordance with the BP/USP limits.

Article Information

Identifiers and Pagination:
Year:2015
Volume:5
First Page:13
Last Page:18
Publisher Id:CanJAppSci (2015 ). 5. 13-18
Article History:
Received:January 15, 2015
Accepted:Accepted: March 21, 2015
Collection year:2015
First Published:April 1, 2015


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights
Abbreviation: Can J Appl Sci
doi: http://dx.doi.org/10.21065/19257430
Frequency: Annual
Current Volume: 7 (2017)
Next scheduled volume: December, 2018  
Back volumes: 1-7
Starting year: 2011
Nature: Online
Submission: Online
Language: English

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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