Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

AN INVITRO STUDY ON EUGENIA JAMBOLANAPLANT EXTRACTIN ISOLATED RABBIT ILIUM SHOWING SPASMOLYTIC EFFECTS
Muhammad Naeem Riaz
1. Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad. Pakistan. 2. Faculty of Pharmacy, University of Central Punjab, Lahore. Pakistan. 3. Dean, Faculty of pharmacy, University of Central Punjab, Lahore. Pakistan. 4. Department of Pharmacology, University of Health Sciences, Lahore. Pakistan.
Keywords: Jamun fruit, Eugenia jambolana, acetylcholine, histamine, serotonin, calcium induced contraction, isolated rabbit ileum
Abstract

Gastrointestinal smooth muscle spasm is the major cause of symptoms of different gastrointestinal disorders. This study was undertaken to examine the effects of Jamun fruit (Eugenia jambolana) extract. The experiment was performed on forty rabbits, properly dissected. Study was performed on Power Lab System. Acetylcholine, histamine, serotonin, and calcium were used in increasing doses to obtain significant contractions in the ilium until the ceiling effect was observed. Thereafter, these drugs were used in the presence of different doses of Jamun extract. Shift of different concentration-response curves in each group was obtained. Percentage inhibition was determined in each group. Statistical analysis showed that in the presence of antagonist dose response curve in acetylcholine and calcium group were more significant than serotonin and histamine, while low doses of serotonin and histamine showed initially spasmogenic effects. Muscle contraction was measured using isometric transducer. Difference in proportions was examined by using ANOVA. Before and after using the drugs, the changes were compared and significance of the study was judged. It can be concluded from current results that Jamun can provide useful spasmolytic effect in different intestinal disorders.

Article Information

Identifiers and Pagination:
Year:2014
Volume:4
First Page:1
Last Page:17
Publisher Id:CanJAppSci (2014 ). 4. 1-17
Article History:
Received:October 7, 2013
Accepted:December 17, 2013
Collection year:2013
First Published:January 1, 2014


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights
Abbreviation: Can J Appl Sci
doi: http://dx.doi.org/10.21065/19257430
Frequency: Annual
Current Volume: 7 (2017)
Next scheduled volume: December, 2018  
Back volumes: 1-7
Starting year: 2011
Nature: Online
Submission: Online
Language: English

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