Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

RESPONSE EVALUATION OF TAMOXIFEN VS AROMATASE INHIBITORS
Saba Mazhar, Mariam Nawaz, Muhammad Tahir Aziz, Sidrah Andleeb
Department of Pharmaceutical Services, SKMCH&RC, Lahore, Pakistan
Keywords: Tamoxifen, aromatase inhibitor, breast cancer
Abstract

Objective:The study was conducted to evaluate the accuracy of use of aromatase inhibitors (AI) and tamoxifen treatment in pre-menopausal and post-menopausal breast cancer patients. Method: The prescription data of 143 patients was reviewed for evaluation of letrozole, anastrazole and tamoxifen utilization between years 2006-2013 at SKMCH&RC. Use was analyzed against pre-menopausal and post-menopausal status of the patients using hospital information software (HIS) for data collection. NCCN Breast Cancer Guidelines were used as reference. Results:Tamoxifen upfront use in pre-menopausal women with breast cancer was 93.3%, while that of Aromatase inhibitor was 6.7%. Tamoxifen was used as second line therapy in pre-menopausal women in 6.7% while aromatase inhibitor was used as second line therapy in pre-menopausal women in 93.3%. Tamoxifen upfront in post-menopausal was 18.6%, aromatase inhibitor upfront in post-menopausal was 81.4%. Conclusion:Tamoxifen is used as first line therapy in majority of pre-menopausal breast cancer patients while aromatase inhibitors are used as second line. In case of post-menopausal breast cancer patients aromatase inhibitors are used as first line in majority of patients while tamoxifen is used as second line.

Article Information

Identifiers and Pagination:
Year:2014
Volume:4
First Page:100
Last Page:104
Publisher Id:CanJAppSci (2014 ). 4. 100-104
Article History:
Received:June 28, 2014
Accepted:September 5, 2014
Collection year:2014
First Published:October 3, 2014


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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