Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

DETECTION OF BIOACTIVE FRACTIONS OF JUSTICIA ADHATODA L. LEAVES
Faiza Rasheed, Waqas Khan Kayani, Adeel Mahmood and Muhammad Gulfraz
1. *Department of Agro systems, P.O Box 104, The Swedish University of Agriculture Sciences, SE 230 53, Alnarp, Sweden 2. Molecular Biology Laboratory, Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan 3. Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan 4. Department of Biochemistry, PMAS Arid Agriculture University Rawalpindi, Pakistan.
Keywords: Justicia adhatoda, Phtochemicals, Antimicrobial compounds, Bioactivity
Abstract

In vitro antibacterial and antioxidant activities of various leaf extracts of Justicia adhatoda L. (locally known as Bhaikar) were assessed. The leaves were also subjected to various phytochemical analysis. Results revealed that leaves of J. adhatoda L. contain significant amount of total alkaloid, phenols flavonoid, saponins, tannins , protein, crude oil, dietary fiber, essential and non essential metal ions. The methanol, ethanol, butanol, chloroform and n-hexane leaf extracts of J. adhatoda significantly inhibited the growth of all bacteria tested as compared to standard antibiotic. However, acetone and aqueous leaf extracts of J. adhaotda were not effective against any bacteria. Methanol extract of J. addhatoda provide lowest Minimum Inhibitory Concentration (MIC) for E. coli (1.0 mg/ml ) followed by Klebsella. pneumoni ( 1.2 mg/ml), where as MIC values of other solvent extracts were in the order of ethanol > chloroform>n-hexane > butanol. The order of antioxidant activities of various leaf extracts found in different solvent extractions was ethanol >methanol >chloroform> water> butanol>. This study will help to promote scientifically use of J. adhatoda in local medicine as well as its use as an important raw material for pharmaceutical industries.

Article Information

Identifiers and Pagination:
Year:2013
Volume:3
First Page:1
Last Page:17
Publisher Id:CanJAppSci (2013 ). 3. 1-17
Article History:
Received:September 19, 2012
Accepted:December 11, 2012
Collection year:2013
First Published:January 1, 2013


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

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  • Chemical Technology
  • Dentistry and Hygiene
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  • Food and Nutrition
  • Health Management
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  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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