SYNTHESIS, SPECTRAL CHARACTERIZATION OF SCHIFF BASE TRANSITION METAL COMPLEXES: ACHE INHIBITOR, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY STUDIES
K. H. Kumar Naik, B. Ashok, Avinash Prakashab, Nagaraja Naika
1. Department of Studies in Chemistry,University of Mysore, Manasagangotri,Mysore-06, India.
2. Department of studies in biotechnology,University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
Keywords: Schiff bases, Metal complexes, Enzymatic activity, DPPH Assay, Antimicrobial activity.
In the present study, we synthesized Novel ligand and their metal complexes with 8-((2-(2,4-dinitrophenyl)hydrazono)methyl)-7-hydroxy-4-methyl-2H-chromen-2-one ligand. The colored complexes were prepared by the addition of chloride salts of Manganese(II), Cobalt(II), Nickel(II) and Copper(II) to a solution of ligand. In conclusion, the structures of the obtained complexes were characterized by FT-IR, elemental analysis, UV-spectral studies, conductmetric and magnetic susceptibility measurements. The synthesized metal complexes were investigated for biological activities. Enzymatic inhibition activity has been done by using acetylcholinesterase (AChE) enzyme, antioxidant activity by DPPH assay and also the antimicrobial studies. All tested metal complexes and ligand reveal effective biological activities.