Canadian Journal of Applied Sciences


ISSN: 1925-7430
Short Key Title: Can J App Sci
DOI: http://dx.doi.org/10.21065/19257430
Start Year: 2011

SEASONAL CHANGES EFFECTS ON THE SEROTONIN AND MELATONIN TRANSMISSION
S.A. Abbas1, U.A. Khan and A.B.M. Helal Uddin
1. School of Pharmacy Taylor’s University College, Malaysia. 2. Faculty of Medicine International Islamic University Malaysia, Kuantan, Malaysia. 3. Faculty of Pharmacy International Islamic University Malaysia, Kuantan, Malaysia.
Keywords: Serotonin, melotonin transmission, depression, calcitriol
Abstract

Neurotransmission of serotonin and its derivative is said to be effected by changing of season in temperate countries. The effect of photoperiod and temperature can alter the production of serotonin and melatonin in body. The depression in serotonin availability in brain leads to a depressive or bipolar disorder. The activity of tryptophan hydroxylase to synthesis serotonin and monoamine oxidase (MAO) to inactivate serotonin is affected by season change. Calcitriol can stimulate tryptophan hydroxylase to produce serotonin. CREM gene works by memorizing work base on previous memory on how much serotonin will be produce. Melatonin it’s a serotonin derivative act as endocrine because it produce from pineal gland and retina. Melatonin has diurnal circadian pattern. Melatonin production is not decline by increasing in age. Arylalkylamine N-acetyltransferase (AA-NAT) gene is one of the cAMP inducible genes is an enzyme important in production of melatonin.

Article Information

Identifiers and Pagination:
Year:2011
Volume:1
First Page:1
Last Page:9
Publisher Id:CanJAppSci (2011 ). 1. 1-9
Article History:
Received:January 11, 2011
Accepted:March 13, 2011
Collection year:2011
First Published:April 1, 2011


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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China

Bibliography

Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights
Abbreviation: Can J Appl Sci
doi: http://dx.doi.org/10.21065/19257430
Frequency: Annual
Current Volume: 7 (2017)
Next scheduled volume: December, 2018  
Back volumes: 1-7
Starting year: 2011
Nature: Online
Submission: Online
Language: English

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