Journal of Applied Molecular Cell Biology


ISSN: 2412-2580
Short Key Title: J App Mol Cell Bio
DOI: http://dx.doi.org/10.21065/24122580
Start Year: 2014

THE CURRENT CHALLENGE OF HCV-RNA RESISTANCE AGAINST DIRECT-ACTING ANTIVIRAL DRUGS.
Nida Taha, Bashir Ahmad
1. M.Phil (Pharmacology) Scholar, Riphah Institute of Pharmaceutical Sciences, Ripah International University Lahore, Pakistan. 2. Professor of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Ripah International University Lahore, Pakistan.
Keywords: HCV-RNA, Resistance, Direct-Acting Antiviral.
Abstract

The HCV-RNA (Hepatitis-C RNA) diagnosed patients are recommended interferon free Direct-Acting Antiviral (DAAs) therapy. Although the treated patients are reported viral resistance to DAAs, the genotype 3a infection is challenge to NS5A inhibitors leading to cirrhosis. Therefore, the patients with chronic Hepatitis-C treated with DAAs, nucleotide analogue inhibitors or NS5B protein have high risk of resistance. Breakthrough or relapse is not common with these drugs when used as monotherapy.NS3-4A protease inhibitors and non-nucleoside inhibitors have low susceptibility to resistance. Sofosbuvir-resistant variants have been discovered that disappear after treatment withdrawal. Patients who experience relapse after an INF-free treatment have large fraction of drug resistant viruses.

Article Information

Identifiers and Pagination:
Year:2018
Volume:5
First Page:1
Last Page:2
Publisher Id:J App Mol Cell Bio (2018 ). 5. 1-2
Article History:
Received:Nov. 13, 2018
Accepted:Dec. 17, 2017
Collection year:2018
First Published:Dec. 21, 2018


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Editor in Chief
Bruno Perillo  (PhD)
Istituto di Scienze dell, Alimentazione, Consiglio Nazionale delle Ricerche, via Roma, 52, 83100 Avellino, Italy.

Bibliography

Dr. Bruno Perillo PhD is associated with Istituto di Scienze dell, Alimentazione, Consiglio Nazionale delle Ricerche, via Roma, 52, 83100 Avellino, Italy. He has contributed in book chapter entitled “Analysis of posttranslational modifications in the control of chromatin plasticity observed at estrogen-responsive sites in human breast cancer cells” Methods Mol. Biol. 1204, 59-69. 2014. Whereas, his research work is published in renowned credible journals.  

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Subject & Scope

  • Genomic analysis
  • Cell or tissue technologies
  • Cellular imaging
  • Gene expression analysis imaging
  • Gene transfe
  • Structural biology  
  • Molecular Cell
  • High throughput screening
  • Medical and small animal
  • Experimental organisms
  • Protein techniques
  • Signal transduction techniques
  • Etymology
  • Molecular genetics
  • Features of inheritance
  • Notation and diagrams
  • Multiple gene interactions
  • DNA and chromosomes
  • Reproduction
  • Recombination and genetic linkage
  • Gene expression
  • Genetic code
  • Nature and nurture
  • Gene regulation
  • Genetic change
  • Mutations
  • Natural selection and evolution
  • Model organisms
  • Medicine
  • Research methods
  • DNA sequencing and genomics
  • Classical, Clinical and Developmental immunology
  • Immunotherapy
  • Diagnostic immunology
  • Cancer immunology
  • Carbohydrates
  • Lipids
  • Proteins
  • Nucleic acids
  • Metabolism
  • Carbohydrates as energy source
  • Glycolysis (anaerobic and aerobic)
  • Gluconeogenesis
  • Molecular cloning
  • Polymerase chain reaction (PCR)
  • Gel electrophoresis
  • Macromolecule blotting and probing
  • Microarrays
  • Allele-specific oligonucleotide

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