HPTLC AND GC-MS PROFILE OF BARLERIA LUPULINA LINDL. EXTRACTS AND THEIR EFFECT ON ENTERIC BACTERIAL PATHOGENS Reshma Kumari, Ramesh Chandra Dubey
Reshma Kumari, Ramesh Chandra Dubey
Department of Botany and Microbiology, Gurukula Kangri Vishwavidyalaya, Haridwar-249404 India.
Keywords: Barleria lupulina, enteric bacteria, extracts, HPTLC and GC-MS profile
Abstract

ABSTRACT The antibacterial activity of acetone, methanol, and water-soluble extracts of both leaf and stem of Barleria lupulina were evaluated against some human pathogens viz., Salmonella typhi, Escherichia coli, Pseudomonas aureginosa, Klebsiella pneumonia and Staphylococcus aureus. The highest antibacterial activities were exhibited at 100% concentrationof all the extracts against the bacterial pathogens. Acetone-soluble leaf (AL) and acetone-soluble stem (AS) extracts caused the maximum zone of inhibition against P. aureginosa, and methanol-soluble leaf (ML) and methanol-soluble stem (MS) extracts against of Salmonella typhi. However, Klebsiella pneumonia was inhibited by all the extracts. The result of HPTLC analysis revealed the presence of alkaloid having different phyto-constituents having their Rf values. Twenty phyto-constituents were identified from all the extracts in which the major compounds were methyl ester, phytol, benzoic acid and propenoic acid as per GC-MS analysis.

Article Information

Identifiers and Pagination:
Year:2016
Volume:8
First Page:61
Last Page:68
Publisher Id:19204159.8:3.2016
Article History:
Received:January 5, 2016
Accepted:May 14, 2016
Collection year:2015
First Published:July 3, 2016


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
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Starting year: 2009
Nature: Online 
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Language: English

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