PHYTOCONSTITUENTS AND EVALUATION OF ACETYLCHOLINESTERASE INHIBITION BY METHANOL EXTRACT OF LIQUIDAMBAR STYRACIFLUA (L.) AERIAL PARTS
National Research Centre, Pharmacognosy Department, Dokki, Giza, Egypt.Federal University of Piaui, Laboratory of Natural Products, Chemistry Department, Ininga, 64049-550, Teresina-Pi, Brazil.
Keywords: Liquidamabar styraciflua, aerial parts, Anticholinesterase activity, Alzheimer’s disease, phytoconstitutents
Abstract

This study deals with evaluation of acetylcholinesterase activity of Liquidambar styraciflua aerial parts methanol 80% extract and identification of the bio-active phytoconstituents of the extract. The acetylcholinesterase inhibition was detected by Ellman’s method and the methanol extract was subjected for phytochemical analysis. The extract of L. styraciflua has shown (IC50 = 0.070 mg/mL), with a similar activity to neostigmine (IC50 = 1.87 µg/mL) and galanthamine (IC50 = 0.37 x10–3 mg/mL) which are the most effective compounds in the treatment of Alzheimer’s disease. Phytochemical investigation of methanol extract of L. styraciflua revealed the presence of triterpenes, flavonoids, tannins and carbohydrates and chromatographic separation and fractionation of methanol extract of L. styraciflua resulted in the isolation of ß-sitosterol, lupeol, oleanolic acid, ursolic acid, luteolin, orientin, isoorientin, kaempferol 3-O-a-rhamnoside and kaempferol 3-O-ß-glucoside. These results suggest that methanol extract of L. styraciflua is a good natural source for acetylcholinesterase inhibitor.

Article Information

Identifiers and Pagination:
Year:2014
Volume:6
First Page:123
Last Page:131
Publisher Id:19204159.6:3.2014
Article History:
Received:January 15, 2014
Accepted:January 27, 2014
Collection year:2014
First Published:April 1, 2014


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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