RAFT FORMING BUOYANT pH DEPENDENT THIXOTROPIC GELLING SYSTEMS INCORPORATED WITH GELUCIRE 43/01 AS A POTENTIAL STOMACH SPECIFIC DRUG DELIVERY SYSTEM FOR FAMOTIDINE
Pallavi Tiwari, Shashank Soni, Veerma Ram, Anurag Verma
Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun (U.K), India. School of Pharmaceutical Sciences, IFTM University, Moradabad (U.P), India
Keywords: Famotidine, in situ gel, buoyant gastro-retentive, Chitosan, Sodium alginate, Gelucire 43/01
Abstract

Famotidine (FMT) is known as a histamine blocker (H2) that inhibits stomach acid production and it is commonly used in the treatment of peptic ulcer disease and gastric-esophageal reflux disease. It has a short half life (2.5-3.5 hours), low bioavailability (40-45%). It has excellent solubility in acidic pH just reverse in alkaline pH. Therefore an attempt has been made to develop raft buoyant gastro-retentive sustains release delivery system with in situ gelling property which is based on thixotropy behavior. Twelve formulations (Excluding two controlled formulations i.e. F and F*) were designed to contain 40 mg of FMT using Chitosan; CH (cationic polymer), Sodium Alginate; SA (anionic polymer), Gelucire 43/01; G 43/01 (lipid phase) as retardant and adhesive polymers. Emulgel was prepared and evaluated for their physicochemical properties like buoyancy and lag time, cumulative % drug release, drug release kinetics and drug excipient interaction studies by thermal studies and functional group characterization. All formulations showed that with the increase in concentration of the polymer, the gel strength increased, but the % drug release decreased F8>F12>F11>F6>F5>F10>F7>F9>F3>F4>F1>F2>F*>F. Formulations F9, F10, and F12 were found to be optimum. They followed the non-ficikian mechanism of drug release.

Article Information

Identifiers and Pagination:
Year:2015
Volume:7
First Page:156
Last Page:172
Publisher Id:19204159.7:3.2015
Article History:
Received:June 13, 2015
Accepted:June 23, 2015
Collection year:2015
First Published:July 1,2016


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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