VANCOMYCIN ASSOCIATED EOSINOPHILIA & RED MAN SYNDROMEIN A TERTIARY CARE HOSPITAL
Adeel Siddiqui, Zuhaib Jaffer Malik, Sidrah Andleeb
Department of Pharmacy, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan. Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan. Department of Pharmacy, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan
Keywords: red man syndrome, vancomycin, drug rash eosinophilia and systemic symptoms, eosinophilia.
Abstract

Vancomycin associated Red Man Syndrome (RMS) is a common infusion related adverse effect. A correlation has been proposed between vancomycin induced eosinophilia and occurrence of RMS.In such cases, it is identified that activated T-cells release cytokines, which tends to contribute to hypersensitivity reaction.A cross-sectional, retrospective study was conducted to evaluate the possible association of vancomycin induced eosinophilia with the occurrence of RMS at a local tertiary care cancer hospital. In this study the role of eosinophilia before the occurrence of RMS was focused. A twenty one month data was extracted from Jan, 2014 to Sep, 2015 and 8 patients were found to be reported for vancomycin induced RMS. Only one patient (12.5%) fulfilled the criteria for the drug rash eosinophilia and systemic symptoms (DRESS) among the 8 patients. This particular patient had eosinophilia preceding RMS. In the study sample,2(25%) patients showed a rise in their eosinophil count but within the normal range.A correlation of eosinophilia and RMScould not be established in our study.

Article Information

Identifiers and Pagination:
Year:2016
Volume:8
First Page:7
Last Page:10
Publisher Id:19204159.8:1.2016
Article History:
Received:October 12,2015
Accepted:November 1,2015
Collection year:2015
First Published:January 1, 2016


© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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