Attempts have been prepared to develop in situ Emulgel of Famotidine by
involving polymers i.e. Chitosan (cationic), Sodium Alginate (anionic) alone or
in varied proportion according to need in the presence of waxy material
Gelucire 43/01 other than this, in situ gelling
system includes some additional advantages in terms of biocompatibility and
biodegradability, these systems are fragile in nature and these systems do not
have any mechanical strength to hold entrapped drug present in it. Including
these hydrophilic polymers with lipid materials has been employed in the
previous time to overcome the hurdle of fast release of drug from the matrices.
An attempt has been made in developing in
situ gelling emulgels using Gelucire 43/01 as a lipid phase and
Sodium Alginate with low viscosity, Chitosan solution in deionized water as an
aqueous phase of an emulsion. Geluciers are glycerides and polyglycerides of
fatty acids. Their ampiphilic nature of the long chain hydrocarbon and the
moieties of alcohol that makes these bases suitable as a lipid carrier for both
types of drugs i.e. hydrophilic and lipophilic drugs. In situ gelling system is one of the
techniques to retain the gel in the gastric environment of the stomach so that
the maximum amount of drug can be released thereby increasing the
bioavailability. The extremely variable nature of gastric emptying time leads
the unpredictable bioavailability and its times to achieve the maximum plasma
levels. Incorporation of drug in the controlled release gastro retentive dosage
form which remains in the gastric region for several times and would
significantly prolong the gastric residence time and improve bioavailability,
reduced drug wastage and enhance solubility of the drugs which are less soluble
in high pH. Famotidine is a drug with short half life and shows solubility in
acidic pH. It is the most popular drug for peptic
ulcer and it belongs to H2 antihistaminic class. Although, broad extensive research is
needed for to confer the formations of polyelectrolyte complex between Chitosan
and Sodium alginate. However, we got some success on these polyelectrolyte
formulations based on in situ gel as
on initial phase.
are thankful to Sardar Bhagwan Singh PG Institute of Biomedical Sciences and
Research, Balawala, Dehradun. Authors are also thankful to the Indian Institute
of Technology, Roorkee (IIT - Roorkee), India and Wadia Institute of Himalyan
Geology, Dehradun, India for characterization of samples in time.
CONFLICTS OF INTEREST
declare no conflicts of interest.
Sriamornsak, P., Asava, P.
(2008). Wax incorporated emulsion gel beads of calcium pectinate for
intragastric floating drug delivery system. Springer link 7: 2571-576
Sriamornsak, P., Thirawong.
(2004). Morphology and buoyancy of oil entrapped calcium pectinate gel beads.
Springer link 6: 365-71
Shimpi, S., Chauhan, B. (2004).
Preparation and evaluation of Deltiazam Hydrochloride-Gelucire 43/01 Floating
granules. AAPS Journals 5: 3124-127
Patel, M., Patel, N. (2007).
Preparation and evaluation of Deltiazam Hydrochloride Gelucire 43/01 Floating
granules by using factorial design. AAPS Journals 8(3): 34-42
Jagdale, SC., Kuchekar, BS.
(2010). Preparation and in vitro
evaluation of Allupurinol-Gelucire50/13 solid dispersion, International Journal
of Pharmaceutical Sciences 6: 60-67
Amsden, B. (2002). Biodegradable injectable in situ forming drug delivery
systems, Journal of Controlled Release 80 (1-3): 9-28
FK. (2012). Development of
modified in situ gelling oral liquid
sustained release formulation of dextromethorphan. Drug Dev Ind
Pharm 38(8): 971-78. doi:
10.3109/03639045.2011.634811. Epub 2011 Nov 18.
Saxena, Ashwin., Mishra, Arun.,
Verma, Navneet., Bhattacharya, Shiv., Ghosh, Amitava., Verma, Anurag., Pandit
K, Jayanta. (2013). Gelucire 43/01 based in
situ gelling emulsions: A Potential carrier for sustained stomach specific
delivery of Gastric irritant drugs. Hindawi Publishing Corporation Biomed
Research international 2013: 1-11
9. Bo, Tang., Gang, Cheng., Jian-Chun, Gu., Cai-Hong,
Xu. (2008). Development of solid self-emulsifying drug delivery systems:
preparation techniques and dosage forms. Drug Discovery
Today 13 ( 13–14):
10. Sophie, R., Van, Tomme., Gert, Storm., Wim E, Hennink. (2008). In situ gelling hydrogels for pharmaceutical
and biomedical applications. International Journal of Pharmaceutics 355 (1–2): 1–18 doi:10.1016/j.ijpharm.2008.01.057
11. Roberta, Censi., Peter
J, Fieten ., Piera di, Martino., Wim
E, Hennink., Tina, Vermonden. (2010). In
Forming Hydrogels by Tandem Thermal Gelling and Michael Addition Reaction
between Thermosensitive Triblock Copolymers and Thiolated Hyaluronan Macromolecules 43 (13): 5771–78 doi: 10.1021/ma100606a
12. Ali, J.,
Arora, S., Ahuja, A., Babbar A, K., Sharma R. K., Khar R, K. (2007).
Formulation and Development of Floating Capsules of Celecoxib: In Vitro and in Vivo Evaluation. AAPS
Pharm Sci Tech. 8 (4): 1-8.
13. Richard, W.,
Korsmeyer Robert, Gurny., Eric,
Doelker., Pierre, Buri., Nikolaos A, Peppas. (1983).Mechanisms of
solute release from porous hydrophilic polymers. International
Journal of Pharmaceutics
15 (1): 25-35.
14. Peppas N,
A., Bures, P., Leobandung, W. (2000). Hydrogel in pharmaceutical formulations:
Eur J Pharm Sci, 50: 27-46.
Ganjoo., Shashank, Soni., Veerma, Ram. (2013). Effect of Release Modifier on
Hydrodynamically Balanced System of Ketoprofen for Sustained Delivery System.
Inventi Impact: NDDS, 2013(4): 283-88.
16. Text on
validation of analytical procedures ICH harmonized tripartite guidelines.
Available at <http://www.ich.org/cache/compo/363-272-1>
17. Badry, M.,
Blum A, L. (2009). The effect of specific gravity and eating on gastric
emptying of slow-release capsules based on Gelucire. New Engl J Med. 304:
18. Nagarwal C, Ramesh., Srinatha, A., Pandit,
.Jayanta. (2009). In situ forming
formulation: Development, Evaluation and optimization using 33 factorial
design, AAPS Pharm SciTech, 10: