COMPARATIVE STABILITY STUDY OF METRONIDAZOLE IN AQUEOUS AND NON AQUEOUS VEHICLE
Satish Nayak, D. C. Goupale*, Atul Dubey and Vipin shukla
Bansal College of pharmacy, Bhopal, India
Keywords: Metronidazole, stability, relative humidity.
Metronidazole is commonly used for the treatment of Helicobacter pylori associated peptic
ulcer. Though the Metronidazole is relatively stable with little degradation in aqueous phase but
its stability is quite higher in non aqueous phase. The current article discusses about the
improvement of stability of metronidazole in non aqueous vehicles which may be useful for the
development of liquid formulations containing this drug. The stability study of the drug was
carried out at different temperatures and relative humidity according to the ICH guidelines. It
was found that the Metronidazole was about 3.7, 4.4, 4.8, 5.3 and 5.9 times more stable in 20%,
40%, 60%, 80% and 100 % v/v propylene glycol solution as compared to aqueous solution at
400C and 75% RH.
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