FORMULATION AND EVALUATION OF NAPROXEN MONOLITHIC SUSTAINED RELEASE MATRIX TABLET
Vinay Wamorkar*1, Pendota Santhosh1, Manjunth S. Y. 1, Rajmohommed M.2
1. Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, RD: Siddipet, Medak (A.P.) 502277, India
2. Ajanta Pharmaceutical Ltd, Charkope, Kandivali (W), Mumbai
Keywords: Naproxen, HPMC, insoluble filler, FT-IR, mathematical models, Non-Fickian
In present investigation the sustained release matrix tablet of naproxen was formulated to study effect various grades of HPMC and insoluble filler. The model is based on a novel dosage form designed to deliver a drug into the gastrointestinal tract in a controlled manner. Matrix tablets were prepared by wet granulation method. As a pre-requisite and part of pre-formulation studies, drug along with selected excipients and as optimized formulation was subjected to FT-IR studies. It was found that no interaction among excipients occurred, as no extra peaks obtained. Tablets were evaluated for various IP-QC tests like hardness, friability, content uniformity, physical appearance and in-vitro release by USP paddle apparatus. Model equations of zero and first order,Higuchi, Hixson-Crowell and Peppas,intended to elucidate the drug release mechanism, were fitted to the release data. Mathematical modeling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with firstorder release kinetics with r2 vales of 0.915, which evidenced that the formulations are useful for a controlled release of naproxen. Simultaneously, from Hixson-Crowell equation shape dependency was also studied with r2 values of 0.973. By Peppas equation the value of r2 for optimized formulation was found to be 0.563and for n value of 0.603. This indicates the release from formulated tablet follows Non-Fickian release mechanism.