RAFT FORMING BUOYANT pH DEPENDENT THIXOTROPIC GELLING SYSTEMS INCORPORATED WITH GELUCIRE 43/01 AS A POTENTIAL STOMACH SPECIFIC DRUG DELIVERY SYSTEM FOR FAMOTIDINE
Pallavi Tiwari, Shashank Soni, Veerma Ram, Anurag Verma
Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun (U.K), India. School of Pharmaceutical Sciences, IFTM University, Moradabad (U.P), India
Keywords: Famotidine, in situ gel, buoyant gastro-retentive, Chitosan, Sodium alginate, Gelucire 43/01
Famotidine (FMT) is known as a histamine blocker (H2) that inhibits stomach acid production and it is commonly used in the treatment of peptic ulcer disease and gastric-esophageal reflux disease. It has a short half life (2.5-3.5 hours), low bioavailability (40-45%). It has excellent solubility in acidic pH just reverse in alkaline pH. Therefore an attempt has been made to develop raft buoyant gastro-retentive sustains release delivery system with in situ gelling property which is based on thixotropy behavior. Twelve formulations (Excluding two controlled formulations i.e. F and F*) were designed to contain 40 mg of FMT using Chitosan; CH (cationic polymer), Sodium Alginate; SA (anionic polymer), Gelucire 43/01; G 43/01 (lipid phase) as retardant and adhesive polymers. Emulgel was prepared and evaluated for their physicochemical properties like buoyancy and lag time, cumulative % drug release, drug release kinetics and drug excipient interaction studies by thermal studies and functional group characterization.
All formulations showed that with the increase in concentration of the polymer, the gel strength increased, but the % drug release decreased F8>F12>F11>F6>F5>F10>F7>F9>F3>F4>F1>F2>F*>F. Formulations F9, F10, and F12 were found to be optimum. They followed the non-ficikian mechanism of drug release.