Figure 5 shows the histological analysis of the
skin sample from the rat models urderwent different treatments. The
histological analysis of the skin sample without MRSA inoculation (Figure 5 E)
showed the presence of healthy hair follicles and sebaceous glands in the
dermis layer. In contrary, the histological analysis of the placebo control
group (Figure 5 A) showed the structure of damaged skin, with no hair follicle
and sebaceous glands. The findings were in agreement with Nichols and Florman
[5, 12] where the hair follicle and sebaceous gland of the skin tissue were
ruptured after infected with MRSA. For the rat models treated with 1% fraction
Ma10 (Figure 5 C), the regeneration of hair follicle was observed in the dermis
layer, marking the improvement in the wound healing. For the drug control and
2% fraction Ma10 test group (Figure 5 D), the histological studies of the skin
were similar to the sample without inoculation, with widespread of hair
follicles and sebaceous glands in the dermis layer of the skin. The results
showed that 2% of fraction Ma10 significantly improve the regeneration of hair
follicles and sebaceous glands of the skin, by inhibiting the growth of MRSA.
The authors are thankful to National Science
Fellowship and USM post-graduate grant scheme for the research grant and
financial support in this study.
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