ASSESSMENT OF CARBIMAZOLE, PROPYLTHIOURACIL & L-THYROXINE FOR LIVER MARKERS IN THYROID PATIENTS FROM PUNJAB, PAKISTAN
Centre for Research in Molecular Medicine, The University of Lahore, Pakistan.Department of Biochemistry, Kinnaird College, Lahore, Pakistan.Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.Department of Pharmaceutical Sciences, Superior University, Lahore, Pakistan.Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.Center for Nuclear Medicine, Mayo Hospital, Lahore, Pakistan.
Keywords: Hepatic dysfunction, carbimazole, propylthiouracil, levothyroxine, thyroid hormones
Hepatic functions dependency on thyroid hormones has been reported in many past studies. Momentous change in physiology and chemistry of thyroid gland not only affects the glandular function but also profoundly impinge working of liver markers causing hepatic dysfunction. Consequently, in order to give better response for thyroid diseases, the efficiency of thyroid drug is also calculated in persuading liver markers towards standard ranges which previously have been disturbed due to thyroid invasion. The current study was aimed with the intent to find effect of thyroid drugs on liver markers in Pakistani thyroid population from Mayo Hospital, Lahore, Punjab. Patients of hyper and hypothyroidism on thyroid drugs were recruited in the study and their thyroid and liver profiles were compared with controlled population. Carbimazole and propylthiouracil were administered to hyperthyroid patients and hypothyroid patients were given levothyroxine. The data was analyzed statistically based on p-values for parameters such as triiodothyronine, thyroxine, thyroid stimulating hormone, aspartate aminotransferase and alanine aminotransferase. Potential results were obtained for all parameters with carbimazole and propylthiouracil but only thyroxine and alanine aminotrasferase were stabilized with levothyroxine. So, we suggest use of adjunctive therapy with levothyroxine to be prescribed in hypothyroidism.