Canadian Journal of Applied Sciences

ISSN: 1925-7430
Short Key Title: Can J App Sci
Start Year: 2011

Sadia Saleem Rao1, Rahila Najam1, Syed Atif Abbas2
1. Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan 2. Jalan Taylor's 47500 Subang Jaya, Selangor Darul Ehsan Malaysia.
Keywords: Alloxan, Momordica charantia, Punica granatum, Lawsonia inermis and Tamarindus indica.

Aim of the study was to examine the efficacy of a combination herbal product from Malaysian market. This herbal product is traditionally being used for managing diabetes mellitus. The herbal combination is a mixture of Momordica charantia, Punica granatum, Lawsonia inermis and Tamarindus indica. The drug was administered orally at the dose of 620mg/70kg once daily for the duration of 42 days to alloxan induced diabetic rats. The effects of this herbal combination were compared with standard drug, sulphonylurea (Glibenclamide). Efficacy of the drug was monitored at intervals with respect to fasting and random glucose levels and glycosylated hemoglobin. Results revealed that the combination of four herbs reduced fasting glucose levels and random glucose levels. HbA1C was observed to be less than 7% by this herbal combination. However, the herbal combination failed to produce the efficacy comparable to the standard drug, Glibenclamide.

Article Information

Identifiers and Pagination:
First Page:7
Last Page:12
Publisher Id:CanJAppSci (2015 ). 5. 7-12
Article History:
Received:October 11, 2014
Accepted:December 13, 2014
Collection year:2014
First Published:January 1, 2015

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Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China


Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights
Abbreviation: Can J Appl Sci
Frequency: Annual
Current Volume: 7 (2017)
Next scheduled volume: December, 2018  
Back volumes: 1-7
Starting year: 2011
Nature: Online
Submission: Online
Language: English

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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