Canadian Journal of Applied Sciences

ISSN: 1925-7430
Short Key Title: Can J App Sci
Start Year: 2011

Saba Mazhar, Mariam Nawaz, Muhammad Tahir Aziz, Sidrah Andleeb
Department of Pharmaceutical Services, SKMCH&RC, Lahore, Pakistan
Keywords: Tamoxifen, aromatase inhibitor, breast cancer

Objective:The study was conducted to evaluate the accuracy of use of aromatase inhibitors (AI) and tamoxifen treatment in pre-menopausal and post-menopausal breast cancer patients. Method: The prescription data of 143 patients was reviewed for evaluation of letrozole, anastrazole and tamoxifen utilization between years 2006-2013 at SKMCH&RC. Use was analyzed against pre-menopausal and post-menopausal status of the patients using hospital information software (HIS) for data collection. NCCN Breast Cancer Guidelines were used as reference. Results:Tamoxifen upfront use in pre-menopausal women with breast cancer was 93.3%, while that of Aromatase inhibitor was 6.7%. Tamoxifen was used as second line therapy in pre-menopausal women in 6.7% while aromatase inhibitor was used as second line therapy in pre-menopausal women in 93.3%. Tamoxifen upfront in post-menopausal was 18.6%, aromatase inhibitor upfront in post-menopausal was 81.4%. Conclusion:Tamoxifen is used as first line therapy in majority of pre-menopausal breast cancer patients while aromatase inhibitors are used as second line. In case of post-menopausal breast cancer patients aromatase inhibitors are used as first line in majority of patients while tamoxifen is used as second line.

Article Information

Identifiers and Pagination:
First Page:100
Last Page:104
Publisher Id:CanJAppSci (2014 ). 4. 100-104
Article History:
Received:June 28, 2014
Accepted:September 5, 2014
Collection year:2014
First Published:October 3, 2014

© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China


Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights
Abbreviation: Can J Appl Sci
Frequency: Annual
Current Volume: 7 (2017)
Next scheduled volume: December, 2018  
Back volumes: 1-7
Starting year: 2011
Nature: Online
Submission: Online
Language: English

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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