Canadian Journal of Applied Sciences

ISSN: 1925-7430
Short Key Title: Can J App Sci
Start Year: 2011

S.A. Abbas1, U.A. Khan and A.B.M. Helal Uddin
1. School of Pharmacy Taylor’s University College, Malaysia. 2. Faculty of Medicine International Islamic University Malaysia, Kuantan, Malaysia. 3. Faculty of Pharmacy International Islamic University Malaysia, Kuantan, Malaysia.
Keywords: Serotonin, melotonin transmission, depression, calcitriol

Neurotransmission of serotonin and its derivative is said to be effected by changing of season in temperate countries. The effect of photoperiod and temperature can alter the production of serotonin and melatonin in body. The depression in serotonin availability in brain leads to a depressive or bipolar disorder. The activity of tryptophan hydroxylase to synthesis serotonin and monoamine oxidase (MAO) to inactivate serotonin is affected by season change. Calcitriol can stimulate tryptophan hydroxylase to produce serotonin. CREM gene works by memorizing work base on previous memory on how much serotonin will be produce. Melatonin it’s a serotonin derivative act as endocrine because it produce from pineal gland and retina. Melatonin has diurnal circadian pattern. Melatonin production is not decline by increasing in age. Arylalkylamine N-acetyltransferase (AA-NAT) gene is one of the cAMP inducible genes is an enzyme important in production of melatonin.

Article Information

Identifiers and Pagination:
First Page:1
Last Page:9
Publisher Id:CanJAppSci (2011 ). 1. 1-9
Article History:
Received:January 11, 2011
Accepted:March 13, 2011
Collection year:2011
First Published:April 1, 2011

© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Xianghui Qi (PhD)
Jiangsu University, Zhenjiang, China


Dr. Xianghui Qi is working as Professor in the School of Food & Biological Engineering, Jiangsu University, China. His research interests: Biosynthesis of high value-added chemicals by microbes and engineered strains; Discovery of novel genes, enzymes and new strains; Rational & Irrational design of microbial enzymes; Isolation, identification and evolution of microbes; Metabolic engineering & Pathway engineering of functional microbes, and biotransformation; Metabolic regulation based on the research of microbial omics; Application of high value-added products including functional sugar alcohols by biosynthesis and biotransformation based on microbial engineered strains.

Journal Highlights
Abbreviation: Can J Appl Sci
Frequency: Annual
Current Volume: 7 (2017)
Next scheduled volume: December, 2018  
Back volumes: 1-7
Starting year: 2011
Nature: Online
Submission: Online
Language: English

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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