Canadian Journal of Biomedical Sciences


ISSN: -
Short Key Title: Can J Biom Sci
DOI: http://dx.doi.org/10.21065/
Start Year: 2016

ADVERSE REACTIONS OF DACARBAZINE IN PEDIATRIC ONCOLOGY; A CASE SERIES FROM A TERTIARY CARE CANCER SPECIALTY HOSPITAL, PAKISTAN
Saleha Nadeem, Ehsan Elahi, Shahbaz Ahmad Khan, Sidrah Andleeb
Department of pharmaceutical services, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
Keywords: Pediatric Hodgkin’s Lymphoma, Adverse Drug Reactions, Dacarbazine, Case Series
Abstract

Hodgkin’s lymphoma in pediatric patients involves chemotherapy drug regimens containing Dacarbazine as a backbone of the therapy. Adverse drug events are the major concerns in the treatment plan of chemotherapy. Here in this case series, we present five cases of Hodgkin’s lymphoma of pediatric age group getting treated with Dacarbazine based chemotherapy either COPDac or ABVD. All patients developed shivering during the infusion. Three of them had fever spikes and one patient happened to have tachycardia. All the events were managed conservatively followed by safe administration of chemotherapy. Four patients are continuing to have treatment as per the plan and one patient is with end of treatment and on follow up. Naranjo’s scale was used for probability assessment of the events and score of 6 was given to all the events, indicating the adverse drug reactions to be probable. A very scarce data and our case series are evocative of further studies to review the administration time of the Dacarbazine as well as the addition of pre-medication before initiation of Dacarbazine infusion.

Article Information

Identifiers and Pagination:
Year:2017
Volume:2
First Page:1
Last Page:5
Publisher Id:Can J Biom Sci (2017 ). 2. 1-5
Article History:
Received:September 11, 2017
Accepted:November 13, 2017
Collection year:2017
First Published:December 21, 2017


© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Sundeep K. Vashist (PhD)
Vallo Med Health Care GmbH, Germany. E.: sandeep.vashist@yahoo.com, sandeep.vashist@vallomed.com

Bibliography

Dr. Sandeep K. Vashist is the Chief Scientific Officer at Vallo Med Healthcare GmbH, Germany. He was the Bioanalytical Scientist at Bristol-Myers Squibb Ireland (2006-2009), Team Leader for point-of-care (POC) diabetic monitoring at National University of Singapore (2009-2012) and Head of Immunodiagnostics at Hahn-Schickard, Freiburg, Germany (2012-2015). His research outputs include many successful technology transfers; several in vitro diagnostic (IVD) and POC technologies; more than 100 high impact factor journal publications and ~100 conference publications; numerous patents; book chapters; invited/keynote/plenary talks; and, several highly prestigious books for CRC Press, Springer Nature and Elsevier. He has constantly received highly prestigious fellowships and awards for scientific research excellence and innovation. He is the Editor for more than 12 highly reputed journals. Besides, he is the expert/reviewer/advisor for many international funding agencies, and a consultant for IVD, POCT and diabetic monitoring and management. His research interests include IVD, POC technologies, bioanalytical sciences, mobile healthcare, and nanotechnology.

Journal Highlights
Key title: Canadian Journal of Biomedical Sciences 
Abbreviation: Can J Biomed Sci
Frequency: Annual
Current Volume: 2 (2017)
Next scheduled volume: December, 2018 (Volume 3)
Back volumes: 1-2
Starting year: 2016
Nature: Online
Submission: Online
Language: English

Indexing

Subject & Scope
  • Biochemistry and Biotechnology
  • Bioinformatics and Biometric
  • Chemical Technology
  • Dentistry and Hygiene
  • Environmental Health, Safety and Allied Sciences
  • Food and Nutrition
  • Health Management
  • Medical Sciences
  • Molecular/ Cellular Biology
  • Pharmaceutical Sciences
  • Pharmacotherapy
  • Theoretical Models (health, life and clinical practice)
  • Veterinary, Fishery and Animal Biology

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