Department of Pharmacy, University of Chittagong, Bangladesh. Department of Pharmacy, Jagannath University, Dhaka, Bangladesh. Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh
Keywords: Super disintegration, Metformin, Immediate release tablet

Immediate release tablet of Metformin HCl needs to formulate for emergency treatment of type-II diabetes. The prime objective of the present research was to formulate immediate release tablet of Metformin HCL for rapid action by using Sodium starch glycolate, Collidon CL and Crosscarmellose Na as super disintegrants.Wet granulationmethod was adapted for the tablet preparation, maize starch used as a diluent, Povidone k-30 as a binder, sodium starch glycolate, collidon CL and crosscarmellose Na as super disintegrants in different concentration (2-5%). Aerosol -200 to provide proper flow characteristics and magnesium stearate as a lubricant. Total nine formations were prepared and evaluated for hardness, thickness, diameter, friability, weight variation, disintegration time and in-vitro drug release. All the formulations were compared for disintegration time and % drug release. All formulations are evaluated for pre-compression and post-compression parameters. The result obtained showed that the selected batch of tablet formulations containing sodium starch glycolate provides a short DT between 40 to 22 seconds, with sufficient crushing strength and acceptable friability.

Article Information

Identifiers and Pagination:
First Page:344
Last Page:350
Publisher Id:19204159.6:4.2014
Article History:
Received:June 4, 2014
Accepted:July 17, 2014
Collection year:2014
First Published:October 1, 2014

© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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  • Pharmaceutics
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