Kesatebrhan Haile Asressu, Tesfahun Kebede Tesema
1Department of Chemistry, College of Natural and Computational Sciences, Haramaya University, P.O.Box:138, Dire Dawa, Ethiopia
Keywords: Antimicrobial activity, Rosmarinus officinalis, Essential oil, GC/MS, 1, 8-cineole

This study has been concerned with determining the chemical composition and antimicrobial activity of essential oil extracted from R. officinalis leaves grown in Ethiopia. The essential oil was obtained by hydrodistillation and yielded clear and intense yellow brownish 1.1% (w/w) oil with pleasant smell. The oil was analyzed by GC/MS and resulted in the identification of 43 compounds, representing 100% of the total oil. The major components of R. officinalis oil were 1, 8-cineole (23.55%), verbenone (18.89%), camphor (15.06%), a-terpineol (6.43%), isoborneol (5.68%), tridecyl acrylate (5.57%), linalool (3.71%), bornyl acetate (3.57%), trans-caryophyllene (3.36%), terpine-4-ol (2.78%) and a-pinene (1.40%). In vitro antimicrobial activities of the essential oil of R. officinalis was determined by paper disk diffusion method and showed moderate antimicrobial activity in both 10 and 20 µL concentrations. Escherichia coli and Staphylococcus aureus were used as test bacterial strain where as Apergillus niger and Fusarium oxysporum were selected as test fungi. The presence of monoterpene and oxygenated monoterpene as the major constituents of the essential oil could be responsible for the moderate antimicrobial activity in this study. The results of this study showed some differences in the antimicrobial activities and chemical composition of the essential oil when compared with similar studies conducted in other countries.

Article Information

Identifiers and Pagination:
First Page:112
Last Page:122
Publisher Id:19204159.6:3.2014
Article History:
Received:January 15, 2014
Accepted:January 27, 2014
Collection year:2014
First Published:April 1, 2014

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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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