Industrial Biotechnology Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia. Plant Pathology Laboratory, School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
Keywords: Endophyte, MRSA, in vivo antimicrobial activity, Penicillium minioluteum.

Methicilin-resistant Staphylococcus aureus (MRSA) can be defined as a strain of S. aureus that gained resistance to a large group of beta-lactam antibiotics, which include penicillin and cephalosporin [1]. MRSA is an opportunistic pathogens and it is most common in infecting immune-compromised patients. The worldwide emergence of MRSA is caused by extensive use of antibiotics in the past few decades. Nowadays, MRSA infection is no longer confined to nosocomial infection, but also appears in healthy people in the community with no established risk factor [2]. The recent emergence community acquired MRSA is mainly involving skin and soft tissue infection [3]. MRSA is specially troublesome in hospitals and nursing homes, where patients with weakened immune system are at greater risk on these multi-drug resistant bacterial strains [4]. Topical applications of antibiotics are the most important component of wound infection therapy [5]. Alternative therapies are being sought for treatment of MRSA and one area of interest is the uses of extracts from natural sources. This study was aimed to evaluate in vivo anti-MRSA activity for the dermal administration of dichloromethane extract of P. minioluteum ED24, an endophytic fungus previously isolated from medicinal herb, O. stamineus. To the best of our knowledge, no scientific evaluation of the therapeutic potentials of this endophytic fungus has been done. Hence this study is very important to evaluate the pharmaceutical potential of this endophytic fungus.

Article Information

Identifiers and Pagination:
First Page:162
Last Page:171
Publisher Id:JAppPharm (2014 ). 6:3. 162-171
Article History:
Received:February 05, 2014
Accepted:February 12, 2014
Collection year:2014
First Published:April 1, 2014

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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