SYNTHESIS, ANTIBACTERIAL, AND ANTIFUNGAL EVALUATION OF NOVEL MANNICH BASES CONTAINING OXADIAZOLE AND PYRAZOLE MOIETIES
Maliki Reddy Dastagiri Reddy, Aluru Raghavendra Guru Prasad, ...
1. Sri Krishnadevaraya University, Anatapur, A.P., India.
2. ICFAI Foundation for higher Education, Hyderabad, A.P., India.
Keywords: 1,3,4-oxadiazole moiety; Pyrazole-3-one moiety; Antibacterial activity; Antifungal activity; Minimum inhibitory concentration
Purpose: To synthesize novel series of compounds containing 1,3,4-oxadiazole and pyrazole-3-one moieties in good yields and to evaluate the antimicrobial activity of title compounds.
Methods: Title compounds were characterized by IR, 1H NMR and mass spectra and evaluated for their antimicrobial activities against certain selected gram-positive bacteria, gram-negative bacteria and fungi by disk diffusion method and broth dilution method.
Results: Fluoro, chloro, bromo, nitro, morphonilyl, piperizynyl, N-methylpiperizine substituted compounds (VII c, d, e, f, i, j and k) showed more antimicrobial activity against than other compounds of the series.
Conclusion: Antimicrobial activity was expressed as the corresponding minimum inhibitory concentration (MIC). The compounds have demonstrated considerable antibacterial and antifungal activities.