U. D. Shivhare, P. B. Suruse, S. S. Varvandkar
College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110. (M.S.) India
Keywords: Aceclofenac, Mucoadhesion, Buccal patch

The main objective of the present study was to improve bioavailability of Aceclofenac and decrease the frequency of dosage form administration by sustained release formulation of the drug from the mucoadhesive drug delivery system. Aceclofenac belongs to the drug class known as NSAIDs. It is normally indicated for the treatment of dental pain, rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is selective cox-2 inhibitor. It has an extensive and highly variable hepatic first pass metabolism following oral administration having half life of 4 h. The usual dose of Aceclofenac is 100 mg twice daily with systemic bioavailability of 40- 50% due to extensive “first-pass” metabolism and has a narrow absorption window. These characteristics make Aceclofenac a suitable drug candidate for mucoadhesive drug delivery system. Aceclofenac containing mucoadhesive buccal patches were prepared by solvent evaporation method. The buccal patches were formulated using polymers HPMC E-15 and Eudragit RL 100 alone and in combination. The buccal patches were evaluated for weight variation, thickness, folding endurance, content uniformity, swelling index, in-vitro diffusion study, in-vitro residence time and in-vitro Mucoadhesive strength. Among five formulations using factorial approach F2 showed maximum release 92.35% upto 8 h.

Article Information

Identifiers and Pagination:
First Page:138
Last Page:150
Publisher Id:JAppPharm (2013 ). 5. 138-150
Article History:
Received:May 12, 2013
Accepted:September 26, 2013
Collection year:2013
First Published:October 1, 2013

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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  • Pharmaceutics
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