Hasanpasha .N Sholapur, Fatima Sanjeri Dasankoppa, N.G.Nangundaswamy, Arunkumar G R
1 KLES College of Pharmacy, Vidyanagar, Hubli-31, Karnataka, India. 2 Dept. of Pharmaceutics, Government College of Pharmacy, Bangalore, Karnataka, India. 3 Fenny pharmacy, New Jersey, USA.
Keywords: Sodium carboxy ethyl guar (SCEG), synthesis, optimization technique (32 factorial design), characterization.

Guar gum is a galactomannan polysaccharide obtained from the dried ripe seeds of Cyamopsis tetragonolobus. The objective of the present study was to derivatise guar gum to SCEG and to overcome limitations of guar gum viz, susceptible to microbial contamination, fall in viscosity on storage and to form a clear aqueous dispersion without imparting color to the formulation. The semisyntheic derivative of SCEG obtained by alcoholic alkali suspension method of guar gum was tried by applying optimization technique (32 factorial design) by altering the 2-chloropropionic acid:guar gum, percentage w/v ratio NaOH and temperature of the reaction mixture. The optimized polymer obtained from the various trials was subjected to physical, chemical and spectral characterization. Characterization revealed that derivatization of the guar gum to sodium carboxy ethyl guar. The derivatised polymer exhibited high stability at all ranges of temperature (50C, 250C, 370C and 450C), controlled rate of hydration, pseudoplastic flow pattern and less susceptibility to microbial contamination. Sodium carboxy ethyl guar solution is more controllable than gaur gum with regard to its thickening, viscosity building, suspending, film forming and excipent in the matrix tablets. The valid application of optimization technique was found to be highly productive in achieving an effective semisynthetic derivative meeting the ideal requirements.

Article Information

Identifiers and Pagination:
First Page:162
Last Page:171
Publisher Id:JAppPharm (2012 ). 4. 162-171
Article History:
Received:February 2, 2012
Accepted:March 28, 2012
Collection year:2012
First Published:April 1, 2012

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
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Starting year: 2009
Nature: Online 
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Language: English

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