Department of Pharmaceutics, Faculty of Pharmacy, Umm Al Qura, University, Holy Makkah, KSA. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan-University, Cairo, Egypt
Keywords: Monoolein cubic particles, monoolein vesicles, Drug transfer, multilamellar vesicles, centrifugation, flow cytometric

Monoolein dispersions are of great importance as a colloidal drug delivery system due to its unique structure. Thus it was important to measure the drug release from such carrier system. Conventional release methods showed many drawbacks. In an attempt to avoid these drawbacks, the transfer of a lipophilic drug model porphyrin from donor monoolein dispersions into acceptor multilamellar vesicles (MLV) was carried out. The measurement of porphyrin transferred was performed after the separation between the donor and acceptor using a centrifugation technique or directly without separation using a flow cytometric technique. The transfer rate and amount of porphyrin from the donor monoolein vesicles to the acceptor MLV was higher than from monoolein cubic particles. This difference in the rate and amount transferred might be attributed to the sponge like structure of the cubic particles. In addition, the cubic bicontinuous phase has a unique structure with a high specific bilayer/water interfacial area. Additionally, transfer experiments are better than the conventional release methods from the point of similarity to the conditions in the blood. In conclusion, the centrifugation and flow cytometric techniques are suitable techniques to study the transfer from the donor monoolein dispersions to the lipophilic acceptor MLV.

Article Information

Identifiers and Pagination:
First Page:182
Last Page:193
Publisher Id:19204159.7:4.2015
Article History:
Received:August 13, 2015
Accepted:September 10, 2015
Collection year:2015
First Published:October 1, 2015

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
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Starting year: 2009
Nature: Online 
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Language: English

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