Asia Parveen1,¥, Muhammad Sajid Hamid Akash2,3,*,¥, Kanwal Rehman2, Muhammad Tariq4, Nureen Zahra1, Tahira Iqbal5
1. Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan. 2. Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. 3. College of Pharmacy, Government College University Faisalabad, Faisalabad, Pakistan. 4. Department of Pharmacy, The University of Lahore, Lahore, Pakistan. 5. Department of chemistry and biochemistry, University of Agriculture Faisalabad, Pakistan.
Keywords: Isoniazid, Biodisposition kinetics, Female volunteers

The aim of the study was to characterize the biodisposition kinetics parameters of Isoniazid after a single oral administration of 150mg tablet Isoniazid. The study was conducted on 6 healthy female volunteers with an average age of 21-22 years and an average body weight of 42-56 kg in the department of chemistry (Biochemistry) university of agriculture Faisalabad, Pakistan. Blood samples were collected after predetermined schedule and drug concentration was determined by using spectrophotometric method. The two compartment model kinetic analysis of plasma isoniazid concentration versus time data revealed estimated values of t1/2 ß, clearance and volume of distribution to be 7.60 ± 3.73h, 4.61± 2.69 1/h and 45.45 ± 22.35L respectively. Moreover, the area under curve (AUC), absorption rate constant (ka) and mean residence time (MRT) were observed to be 38.16± 13.76, 0.76±0.12 and 9.53± 4.21 respectively. In conclusion, the pharmacokinetic parameters observed for isoniazid in current study were found to be significantly different from some of the previously reported literature, suggesting that an adequate and rational dosage regimen of drug requires a disposition study of parameters under specific indigenous environment prior to their administration.

Article Information

Identifiers and Pagination:
First Page:227
Last Page:232
Publisher Id:JAppPharm (2012 ). 4. 227-232
Article History:
Received:June 3, 2012
Accepted:September 15, 2012
Collection year:2012
First Published:October 1, 2012

© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

Subject & Scope
  • Pharmaceutics
  • Physical Pharmacy 
  • Dosage Forms Science 
  • Pharmaceutical Microbiology & Immunology 
  • Industrial Pharmacy 
  • Bio-Pharmaceutics 
  • Pharmaceutical Chemistry 
  • Pharmaceutical Instrumentation 
  • Medicinal Chemistry 
  • Pharmacognosy 
  • Physiology &Histology 
  • Anatomy & Pathology 
  • Pharmacology & Therapeutics 
  • Pharmacy Practice 
  • Pharmaceutical Mathematics   
  • Biostatistics 
  • Dispensing 
  • Community Social & Administrative Pharmacy 
  • Hospital Pharmacy 
  • Clinical Pharmacy 
  • Pharmaceutical Quality Management 
  • Forensic Pharmacy 
  • Pharmaceutical Technology 
  • Pharmaceutical Management & Marketing

Consortium Publisher is an online publisher that enjoys global presence with International Journals

Follow Us

©2009 - 2019 Consortium Publisher Canada

Contact Info

6252 Lisgar Dr Mississauga Ontario L5N7V2 Canada
+1 (647) 526-0885