Sheeja Edvin Jerald1, Ajeet Pandey2, Papiya Bigoniya2* and Shilpi Singh2
1 B.R. Nahata College of pharmacy, Mahu Neeemuch road, Mandsaur, India 2 Department of Pharmacognosy and Pharmacology, Radharaman College of Pharmacy, Bhadbhada Road, Ratibad, Bhopal, India
Keywords: Antifertility, Antiovulatory, cucurbetaceae, Momordica charantia Descourt; spermicidal

Momordica charantia Descourt (Cucurbetaceae) known as Karela is an extremely bitter vegetable, commonly found in India. M. charantia had reported anticancer, antidiabetic, antihypertensive, anti- inflammation and antioxidant properties. It is used as antifertility agent in folklore; however no studies have been done on its antifertility action. Anti-fertility potential of the M. charantia hydroalcoholic extracts of seed and pulp was explored on in vitro spermicidal, antiovulatory, in vivo estrogenic and anti-estrogenic activity along with uterus histopathology. Data were presented as M ? SEM and analyzed with ANOVA followed by t-test. MCHS and MCHP are tested for its antifertility activity at doses of 200 mg/kg and 400 mg/kg, orally as it was found safe on acute dosing of 2000 mg/kg. Pulp extract at 1280 µg/ml concentration caused significant damage to the sperm membrane integrity as evidenced by the reduction in sperm viability and tail curling. Administration of pulp extract at 400 mg/kg dose caused significant (p < 0.001) increases in uterine weight in immature rats while co-administration with ethinylestradiol decreased the uterus weight and increased the height of luminal epithelium with stimulated glands. Pulp extract at 400 mg/kg dose also caused significant (p < 0.001) prolongation estrous cycle and diestrous phase. Among the two extracts tested at two different doses, the hydroalcoholic pulp extract of M. charantia at 400 mg/kg was found to exhibit antifertility activity may be due to rich presence of triterpenoidal glycosides, flavonoids and alkaloids.

Article Information

Identifiers and Pagination:
First Page:249
Last Page:263
Publisher Id:JAppPharm (2012 ). 4. 249-263
Article History:
Received:July 1, 2012
Accepted:September 13, 2012
Collection year:2012
First Published:October 1, 2012

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
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Starting year: 2009
Nature: Online 
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