Haroon Khan1, Muhammad Farid Khan1, Syed Umer Jan1, Kamran Ahmad Khan1, Kifayat Ullah Shah1 And Ameer Badshah3
1Faculty of Pharmacy, Gomal University Dera Ismail Khan (KPK) Pakistan 2 Department of Pharmacy, University of Balochistan, Quetta Pakistan
Keywords: Aluminium (Al), Glutathione (GSH), Ellman’s method. 5, 5-Dithiobis, 2-Nitrobenzoic Acid (DTNB)

Aluminium is an important metalloelement and has many medicinal uses like use of aluminum as an antacid. Thus it is interesting to study the effect of Aluminium on the glutathione (GSH) in vivo conditions. The concentration and time dependent effect of Aluminium on glutathione level in plasma was studied by using Ellman’s method. A drastic effect on decreasing the concentration of glutathione level in plasma was found by increasing the concentration of Aluminium sulphate over the time. The reason could probably be due to oxidation of GSH to corresponding disulphide (GSSG). In this paper the effect of Aluminium metal on thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction.

Article Information

Identifiers and Pagination:
First Page:279
Last Page:288
Publisher Id:JAppPharm (2011 ). 3. 279-288
Article History:
Received:March 13, 2011
Accepted:June 10, 2011
Collection year:2011
First Published:July 9, 2011

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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