FABRICATION AND DEVELOPMENT OF ONCE-DAILY LORNOXICAM BI-LAYER MATRIX TABLETS: FOR THE EFFECTIVE TREATMENT OF ARTHRITIS
Qamar Jamal Ahmad1, Hariprasanna R.C1, Upendra kulkarni1*, Basawaraj S.Patil1, Rabbani G1a
1Department of Pharmaceutics, RMES’S College of Pharmacy, Gulbarga, India
1aDepartment of Pharmacology, RMES’S College of Pharmacy, Gulbarga, India
Keywords: Lornoxicam, Bi-Layer Tablet, Arthiritis, HPMCK-15M
The aim of this study was to prepare bi-layer tablet of Lornoxicam (LOR) for the effective treatment of arthiritis. LOR was formulated as immediate release layer and sustained release layer using hydrophilic matrix (hydroxypropylmethylcellulose [HPMC K15M]). The effect of concentration of hydrophilic matrix (HPMC K15M), binder (polyvinyl- pyrollidone [PVP K30]) and dissolution study of sustained release layer showed that an increasing amount of HPMC or PVP K30 results in reduced Lor release. The most successful formulation of the study, exhibited satisfactory drug release in the initial hours, and the total release pattern was very close to the theoretical release profile. All the formulations exhibited diffusion-dominated drug release.
© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made.
You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions
You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits