Vinay Wamorkar*1, Pendota Santhosh1, Manjunth S. Y. 1, Rajmohommed M.2
1. Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, RD: Siddipet, Medak (A.P.) 502277, India 2. Ajanta Pharmaceutical Ltd, Charkope, Kandivali (W), Mumbai
Keywords: Naproxen, HPMC, insoluble filler, FT-IR, mathematical models, Non-Fickian

In present investigation the sustained release matrix tablet of naproxen was formulated to study effect various grades of HPMC and insoluble filler. The model is based on a novel dosage form designed to deliver a drug into the gastrointestinal tract in a controlled manner. Matrix tablets were prepared by wet granulation method. As a pre-requisite and part of pre-formulation studies, drug along with selected excipients and as optimized formulation was subjected to FT-IR studies. It was found that no interaction among excipients occurred, as no extra peaks obtained. Tablets were evaluated for various IP-QC tests like hardness, friability, content uniformity, physical appearance and in-vitro release by USP paddle apparatus. Model equations of zero and first order,Higuchi, Hixson-Crowell and Peppas,intended to elucidate the drug release mechanism, were fitted to the release data. Mathematical modeling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with firstorder release kinetics with r2 vales of 0.915, which evidenced that the formulations are useful for a controlled release of naproxen. Simultaneously, from Hixson-Crowell equation shape dependency was also studied with r2 values of 0.973. By Peppas equation the value of r2 for optimized formulation was found to be 0.563and for n value of 0.603. This indicates the release from formulated tablet follows Non-Fickian release mechanism.

Article Information

Identifiers and Pagination:
First Page:416
Last Page:430
Publisher Id:JAppPharm (2011 ). 3. 416-430
Article History:
Received:May 24, 2011
Accepted:August 24, 2011
Collection year:2011
First Published:October 13, 2011

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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