Tahira Mughal1, Ismat Naeem2, Sadia Qureshi 3, Ammara Abass2
1. Department of Botany, Lahore College for Women University, Jail Road, Lahore, Pakistan 2. Department of Chemistry, Lahore College for Women University, Jail Road, Lahore Pakistan 3. Department of Biochemistry, Avicenna Medical College, Bedian Road Lahore, Pakistan
Keywords: Heliotropium sterigosum is an annual herb found in south Punjab of Pakistan. Extract of whole plant in methanol was tested for anti bacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pneumoniae, Bacillus subtilus, and Sarcina lutae. Minimum Inhibitory Concentration of methanolic extract was determined and found to be bactericidal in concentration of 1000 µg/ml against streptococcus pneumoniae, Escherichia coli, and Streptococcus pneumoniae. Synergistic antibacterial activity of methanolic extracts was tested with respective solvent extracts of seeds of Withania coagulans, whole plant of Hypericum perforatum and Pinus roxburgii (bark). Staphylococcus aureus was synergistically inhibited by methanolic extract of Heliotropium sterigosum and Pinus roxburgii (bark) (1µg/ml) and Withania coagulans (1µg/ml). Methanolic extract of Heliotropium sterigosum inhibits the growth of Sarcina lutae in combination with Pinus roxburgii (bark) methanolic extract (0.5µg/ml). Highest synergistic activity was observed by Heliotropium sterigosum and Withania coagulans methanolic extracts against Pseudomonas aeruginosa (0.5µg/ml) and Bacillus subtilus (1µg/ml).

Heliotropium sterigosum, antibacterial activity, synergistic activity, Withania coagulans, Pinus roxburgii and Hypericum perforatum.

Article Information

Identifiers and Pagination:
First Page:27
Last Page:36
Publisher Id:JAppPharm (2010 ). 2. 27-36
Article History:
Received:November 13, 2009
Accepted:January 5, 2010
Collection year:2009
First Published:January 13, 2010

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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