Taha Nazir, Tahir Aziz Mughal
Biochemistry, Chemical Pathology, Molecular & Microbiology Research Group, University Medical & Research Centre, University of Sargodha, Sargodha 40100 Pakistan. Shaukat Khanum Memorial Cancer Hospital and Research Centre, Johar Town, Lahore, Pakistan.
Keywords: Pharmaceutical care, clinical services, Punjab Institute of Cardiology

Punjab Institute of Cardiology; sad demise of cardiac patients The demise of cardiac patients, registered to Punjab Institute of Cardiology, Lahore, in various hospitals due to therapeutical and pharmaceutical error is a grim concern, needs to be addressed on priority. Initially; as per newspapers, there are two types of reports; use of expired or spurious drugs, supplied by the free pharmacy of the hospital that has been closed after the incidences, and Drugs Testing Laboratory’s reports rejecting the claim of expiry or spuriousness. Such conflicting reports necessitate a multi-level – clinical, medicine, pharmaceutical care and drug analysis - enquiry to avoid such grave prevalence in future because it is well documented that prescribing errors, dispensing errors and irrational use of drugs have killed more people than any disease. Thus; eventually a breakthrough occurred by a press conference on Wednesday, Chief Minister Shahbaz Sharif revealed that Isotab tablets, which are meant for heart patients, had been contaminated with an anti-malarial chemical, which resulted in fatalities to patients who used it daily. The medicine was given free of cost to patients of the Punjab Institute of Cardiology (PIC). There were dangerous quantities of Pyrimethamine, in Isotab added by mistake during manufacturing process in industry [1]. Pyrimenthamine is also found in Fansidar, an antimalarial drug. That reduces folic acid, responsible for production of body and cell components in living organisms [2]. Isotab is given to heart patients twice daily to lessen the burden on their heart. The chemical found in Isotab, however, was equal to 10 tablets of Fansidar, which means those who used this medicine twice a day were effectively taking 20 tablets of Fansidar, which suppressed the bone marrow, disturbed blood production, and ultimately caused death. Isotab was not expect to be contaminated because it’s manufactured by Efroze Chemical Industries, who have around 80 registered medicines in Pakistan.

Article Information

Identifiers and Pagination:
First Page:109
Last Page:111
Publisher Id:19204159.7:2.2015
Article History:
Received:March 10, 2015
Accepted:March 21, 2015
Collection year:2015
First Published:July 1,2016

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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany


Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

Subject & Scope
  • Pharmaceutics
  • Physical Pharmacy 
  • Dosage Forms Science 
  • Pharmaceutical Microbiology & Immunology 
  • Industrial Pharmacy 
  • Bio-Pharmaceutics 
  • Pharmaceutical Chemistry 
  • Pharmaceutical Instrumentation 
  • Medicinal Chemistry 
  • Pharmacognosy 
  • Physiology &Histology 
  • Anatomy & Pathology 
  • Pharmacology & Therapeutics 
  • Pharmacy Practice 
  • Pharmaceutical Mathematics   
  • Biostatistics 
  • Dispensing 
  • Community Social & Administrative Pharmacy 
  • Hospital Pharmacy 
  • Clinical Pharmacy 
  • Pharmaceutical Quality Management 
  • Forensic Pharmacy 
  • Pharmaceutical Technology 
  • Pharmaceutical Management & Marketing

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