SUPPRESSION OF FERTILITY IN MALE RATS BY HYDROETHANOLIC EXTRACT OF ACHYRANTHES ASPERA
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi-110025, India.Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, Munirka, New Delhi-110067, India
Keywords: Achyranthes aspera, testosterone, histology, antioxidant enzymes, infertility
Abstract

The present study was designed to explore antifertility efficacy of Achyranthes aspera in male rats and to study different reproductive parameters related to male reproduction after in vivo exposure to understand the possible mechanism involved in it. Male rats were exposed to Achyranthes aspera hydroethanolic extract at doses of 100 and 200 mg/kg for 60 days. Histological studies revealed that Achyranthes aspera hydroethanolic extract caused degeneration of Leydig cells, spermatogenic disruption and shrinkage of seminiferous tubules in the testis. Seminal vesicle and prostate secretions were blocked and comparatively less population of spermatozoa were seen in the lumen of epididymis. The serum testosterone level reduced significantly. The implantation sites in female rats were drastically reduced after treated males were mated with normal cyclic females. The level of non-enzymic and enzymic antioxidants like GSH, catalase, SOD, GPx, GR and GST were significantly lowered. Toxicity studies showed very minimal or no significant changes in the level of serum AST, ALT and creatinine of liver and kidney. It can be concluded that infertility in male rats could be due to impairment of reproductive performance as indicated by reproductive tract lesions, reduction in the level of testosterone and decrement in the levels of antioxidant enzymes.

Article Information

Identifiers and Pagination:
Year:2014
Volume:6
First Page:135
Last Page:144
Publisher Id:19204159.6:3.2014
Article History:
Received:March 20, 2014
Accepted:March 29, 2014
Collection year:2014
First Published:April 1, 2014


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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