EVALUATION OF INTRAVITREAL BEVACIZUMAB FOR ITS SYSTEMIC SIDE EFFECT THROMBOSIS AFTER CHRONIC ADMINISTRATION
Anila Naz, Rahila Najam, Bushra Riaz, Arsalan Ahmed
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.Layton Rehmatullah Benevolent Trust, Lahore, Pakistan.
Keywords: Bevacizumab, thrombosis, intravitreal.
Abstract

Bevacizumab targets Vascular endothelial growth factor-A (VEGF-A). Bevacizumab specifically binds to the VEGF-A protein, thereby inhibiting the process of angiogenesis.Thrombosis and hypertension are the major systemic side effects of bevacizumab.As thrombosis and hypertension are the major systemic side effects of bevacizumab whether this drug couldpredispose a patient to thrombosis or not after intravitreal administration, as it is absorbed even through intravitreal administration. We determined the safety of the drug.This study was conducted at Al Ibrahim eye hospital for 3months. The drug wasintravitrealy administered by Professor Dr.P.S.Mahar.For this 10 patients were administered three doses of intravitrealbevacizumab at monthlyinterval and followed for chronic effects of drug. Blood samples were taken to determine fibrinogen level, platelet count,prothrombin time (PT), activated partial thromboplastin time (APTT) andsodium level by kit method. Blood pressure was also monitored of all the patients before and after the drug administration.There has been significant decrease seen in fibrinogen level. Non-significant rise in the PT.Platelet counts decrease insignificantly. Slight increase is noted in sodium level.Slight increase is noted in diastolic blood pressure where as systolic blood pressure is insignificantly increased.Thus results of our study indicate that there may be bleeding tendency after bevacizumab so careful monitoring is required in patients receiving this drug, as well as monitoring of blood pressure is required.

Article Information

Identifiers and Pagination:
Year:2014
Volume:6
First Page:179
Last Page:186
Publisher Id:JAppPharm (2014 ). 6:3. 179-186
Article History:
Received:March 10, 2014
Accepted:March 24, 2014
Collection year:2014
First Published:April 1, 2014


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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