DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHODS AND VALIDATION FOR ESTIMATION OF TRAMADOL HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY ABSORBANCE MAXIMA AND AREA UNDER THE CURVE METHOD
Mustafa Sayed, GauriBapat, NazmaInamdar
Department of Quality Assurance, MCE Society’s Allana College of Pharmacy, Azam Campus, Camp, Pune-411018
Keywords: Tamadol Hydrochloride, UV spectrophotometry Absorbance maxima method and ICH guidelines.
Abstract

We aimed this study to develop simple and economic UV spectrophotometric method for estimation of Tramadol Hydrochloride in bulk and tablet dosage form and validate as per ICH guidelines. Method involved Absorbance maxima method which based on the measurement of absorbance of Tramadol Hydrochloride in methanol: water (60:40 % v/v) at?max of 271 nm. The developed method was validated for linearity, precision, accuracy, LOD and LOQ as per ICH guidelines. Theproposed method was found to be linear within the conc. range of 30-150µg/ml for Tramadol Hydrochloride. The present methods were found to be simple, linear, precise, accurate and sensitive and can be used for routine quality control analysis for the estimation of Tramadol Hydrochloridein bulk and tablet dosage form.

Article Information

Identifiers and Pagination:
Year:2014
Volume:6
First Page:198
Last Page:204
Publisher Id:JAppPharm (2014 ). 6:3. 198-204
Article History:
Received:February 17, 2014
Accepted:March 19, 2014
Collection year:2014
First Published:April 1, 2014


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

Subject & Scope
  • Pharmaceutics
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