SIMULTANEOUS QUANTIFICATION OF LORNOXICAM/ PARACETAMOL TABLETS BY APPROACH OF FIRST DERIVATIVE UV-SPECTROSCOPY
Swetha Bhavani N
Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Osmania University, Hyderabad, Andhra Pradesh-500090, India
Keywords: Lornoxicam, paracetamol, derivative spectrophotometry.
Abstract

Background: Derivative spectroscopy provides a greater selectivity and spectral discrimination than common spectroscopy. It is the dominant approach for resolution of one analyte whose peak is hidden by a large overlapping peak of another analyte in multi component analysis. Hence, this technique we have been successfully applied for simultaneous quantification of lornoxicam and paracetamol in combined tablets. Materials and Methods: The method is based on the derivative spectrophotometric method at zero-crossing wavelengths. Two wavelengths 347 nm (zero crossing point for paracetamol) and 272.5nm (zero crossing point for lornoxicam) were selected for the quantification of lornoxicam and paracetamol respectively, using 0.01 M sodium hydroxide as solvent and Shimadzu (Japan) UV-Visible spectrophotometer (UV-1800) instrument. Results: The first derivative amplitude-concentration plots were rectilinear over the range of 2-22 µg/mL and 1-75 µg/mL with detection limits of 0.06 and 0.08 µg/mL and quantification limits of 0.2 and 0.26 µg/mL for lornoxicam and paracetamol respectively. The proposed method was statistically validated as per ICH guidelines. The percentage recovery was within the range between 97-101 and % relative standard deviation for precision and accuracy of the method was found to be less than 2. Conclusion: The proposed method was effectively applied to routine quality control analysis of studied drugs in their tablet formulations.

Article Information

Identifiers and Pagination:
Year:2013
Volume:5
First Page:50
Last Page:58
Publisher Id:JAppPharm (2013 ). 5. 50-58
Article History:
Received:January 5, 2013
Accepted:March 3, 2013
Collection year:2013
First Published:April 1, 2013


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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