EFFECT OF PUNICA GRANATUM (POMEGRANATE) FRUIT EXTRACT ON ANGIOGENESIS
Ghulam Jilany Khan, Muhammad Ovais Omer, Muhammad Ashraf, ...
1. Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan. 2. Assistant Professor, Department of Pharmacology and Toxicology, College of Pharmacy. Umm Al- Qura University - Al-Abidiyya, Makkah, Kingdom of Saudi Arabia 3. Department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. 4. Department of Botany, Government College University, Lahore, Pakistan.
Keywords: Pomegranate, Angiogenesis, Chorioallantoic membrane assay, Scanning Probe image processing system.
Abstract

Angiogenesis, which is the development of blood vessels from previously existing vessels, is a physiological process. It is a common and most important process in the formation and development of blood vessels, so it is supportive in healing of wound and granulation tissue. This study was designed to evaluate the effect of pomegranate whole fruit extract on angiogenesis by using CAM assay and to verify either the extract is angiogenic or anti-angiogenic. To explore the effect on angiogenesis we used CAM model which is an extra-embryonic membrane model in Chicken embryos and SPIP (scanning probe image processor) for quantification of resultant images. For this study fertilized eggs were collected from a local hatchery in Lahore and different aqueous dilutions of whole fruit extract were applied on developing CAM on day 6. A noticeable reduction in surface roughness of the blood vessels was observed. The diameter of tertiary, secondary and primary blood vessels was also reduced as compared to the blood vessels of control group CAM. The maximum effect was seen with 0.5% dilution. The study proved that Punica granatum (Pomegranate) fruit extract was anti-angiogenic and can be included in the studies for the development of new drug studies to treat cancer (as an anti angiogenic agent).

Article Information

Identifiers and Pagination:
Year:2013
Volume:5
First Page:59
Last Page:75
Publisher Id:JAppPharm (2013 ). 5. 59-75
Article History:
Received:April 27, 2013
Accepted:June 13, 2013
Collection year:2013
First Published:July 1, 2013


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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