SYNTHESIS, ANTIBACTERIAL, AND ANTIFUNGAL EVALUATION OF NOVEL MANNICH BASES CONTAINING OXADIAZOLE AND PYRAZOLE MOIETIES
Maliki Reddy Dastagiri Reddy, Aluru Raghavendra Guru Prasad, ...
1. Sri Krishnadevaraya University, Anatapur, A.P., India. 2. ICFAI Foundation for higher Education, Hyderabad, A.P., India.
Keywords: 1,3,4-oxadiazole moiety; Pyrazole-3-one moiety; Antibacterial activity; Antifungal activity; Minimum inhibitory concentration
Abstract

Purpose: To synthesize novel series of compounds containing 1,3,4-oxadiazole and pyrazole-3-one moieties in good yields and to evaluate the antimicrobial activity of title compounds. Methods: Title compounds were characterized by IR, 1H NMR and mass spectra and evaluated for their antimicrobial activities against certain selected gram-positive bacteria, gram-negative bacteria and fungi by disk diffusion method and broth dilution method. Results: Fluoro, chloro, bromo, nitro, morphonilyl, piperizynyl, N-methylpiperizine substituted compounds (VII c, d, e, f, i, j and k) showed more antimicrobial activity against than other compounds of the series. Conclusion: Antimicrobial activity was expressed as the corresponding minimum inhibitory concentration (MIC). The compounds have demonstrated considerable antibacterial and antifungal activities.

Article Information

Identifiers and Pagination:
Year:2013
Volume:5
First Page:76
Last Page:88
Publisher Id:JAppPharm (2013 ). 5. 76-88
Article History:
Received:May 11, 2013
Accepted:June 17, 2013
Collection year:2013
First Published:July 1, 2013


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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