SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 4,8-DISUBSTITUTED-3,4-DIHYDRO-6-METHYL-IMIDAZO[1,5-b][1,2,4]TRIAZIN-2(8H)-ONE DERIVATIVES.
Atul Baravkar, Sanjay Sawant, Aniruddh Chabukswar, ...
1. *Department of Pharmaceutical Chemistry, Karpagam University, Coimbatore, Tamilnadu, India-641021. 2. Department of Pharmaceutical Chemistry, STES’s SKN College of Pharmacy, University of Pune, Kondhwa, Pune, India-411048. 3. Department of Pharmaceutical Chemistry, Maharashtra Institute of Pharmacy, University of Pune, Kothrud, Pune, India-411038
Keywords: Earlenmeyer-Azlactone synthesis, DPPH, Radical scavenging assay, Ascorbic acid.
Abstract

Purpose: The main objective of the present research study is to synthesize series of novel 4,8-disubstituted disubstituted-3,4-dihydro-6-methyl-imidazo[1,5-b][1,2,4]triazin-2(8H)-one derivatives (5a-5f) and evaluate them for their antioxidant effect. Methods: The said compounds were synthesized in total three steps viz Earlenmeyer-Azlactone synthesis, followed by reaction with substituted and unsubstituted 2, 4-dinitrophenylhydrazine and lastly reaction with chloracetamide. In vitro antioxidant study was performed using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay using various concentrations such as 10, 20, 30, 40 and 50 µg/mL. Synthesis of compounds was confirmed by melting point, HPTLC, FTIR, 1H NMR, 13C NMR and LC-MS. The obtained results (IC50 values) were compared with standard antioxidant agent ascorbic acid. Results: The IC50 values were compared with standard antioxidant ascorbic acid. Compound 5a, 5b and 5c showed very higher significant activity (p<0.01), 5d showed significant activity while compound 5e and 5f showed marginally significant activity. Conclusion: Compounds bearing electron donating group showed higher antioxidant effect as compared to the compounds with electron withdrawing groups.

Article Information

Identifiers and Pagination:
Year:2013
Volume:5
First Page:107
Last Page:117
Publisher Id:JAppPharm (2013 ). 5. 107-117
Article History:
Received:July 10, 2013
Accepted:September 17, 2013
Collection year:2013
First Published:October 1, 2013


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
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Language: English

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