STUDIES ON CORE IN COAT GASTRORETENTIVE TABLETS USING POROUS CARRIERS WITH CELLULOSIC POLYMERS AND NATURAL GUMS
Putta Rajesh Kumar, Hiremath Doddayya and S. Rajendra Reddy
Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur -584103, Karnataka, India.
Keywords: Floating tablet, porous carrier, xanthan gum, guar gum and duodenal ulcer.
Abstract

The present study was aimed to develop a gastroretentive tablet that could deliver antibiotic in stomach from the coat tablet for localized action and acid liable anti secretory agent in duodenum from the enteric coated core. During tablet formulation Studies on rheological characteristics of Clarithromycin coat granular blends showed their free flowing nature and ease for compression to tablet. The compressed tablets exhibited uniform post compressional characteristics. Evaluation of floating parameters indicated results suits for the tablets to formulate core in coat tablets for release of Clarithromycin in gastric pH and esomeprazole in alkaline pH to treat peptic ulcer disease associated with h pylori bacteria. The formulations exhibited uniform rheological and post compressional properties. The drug content was found to be uniform and consistent in all formulations. The tablet showed density < 1 facilitated tablets floating ability over 0.1N HCl with minimum floating lag time. In vitro release studies showed that T6C6 formulation exhibited better release for both the drugs in simulated gastric and intestinal fluids for 12 h. The study revealed the role of porous carriers, cellulosic polymers and natural gums on drug release profiles of esomeprazole core in clarithromycin coat gastroretentive tablets in duodenal ulcer treatment.

Article Information

Identifiers and Pagination:
Year:2012
Volume:4
First Page:73
Last Page:85
Publisher Id:JAppPharm (2012 ). 4. 73-85
Article History:
Received:November 16, 2011
Accepted:January 5, 2012
Collection year:2011
First Published:January 20, 2012


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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