SOLUBILITY ENHANCEMENT OF CARVEDILOL USING LIQUISOLID COMPACT TECHNIQUE
Tarique Ali Meer, Ajay Sav, Purnima Amin
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, 400019. India.
Keywords: Solubility Enhancement, Liquisolid Compacts, BCS Classification, Carvedilol
Abstract

A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Effect of storage conditions on dissolution profile was also studied. DSC and XRD studies were done to confirm the physical state of CAR in the formulation.

Article Information

Identifiers and Pagination:
Year:2012
Volume:4
First Page:103
Last Page:108
Publisher Id:JAppPharm (2012 ). 4. 103-108
Article History:
Received:November 14, 2011
Accepted:January 7, 2012
Collection year:2011
First Published:January 20, 2012


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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